Tag: blood clotting

Questions Related to blood clotting

Blood clotting vitamin is?

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  1. A

  2. $B _6$

  3. $B _{12}$

  4. K

Show answer
Correct Option: D
Explanation:

Vitamin K plays a key role in helping the blood clot, preventing excessive bleeding. Unlike many other vitamins, vitamin K is not typically used as a dietary supplement. Vitamin K is actually a group of compounds. The most important of these compounds appears to be vitamin K1 and vitamin K2


So, the correct answer is 'K'.

When whole blood is stored with an anticoagulant at $4^oC$, the K+ ions move out from the RBC into the plasma. The most likely reasons for this is that

biology soldiers of defense blood clotting and healing of wounds coagulation of blood blood clotting

  1. RBC haemolyses and hence leakage of K+ ions

  2. K+ ions become more mobile at $4^oC$

  3. Active transport ceases resulting in ionic equilibrium

  4. The anticoagulant attracts the K+ ions into the plasma

Show answer
Correct Option: B

Which of the following statements are correct?


(i) $Ca^{+2}$ is necessary for blood coagulation.
(ii)Coagulation in blood vessel is prevented during normal condition by heparin.
(iii)Clotting of blood involves changes of fibrinogen to fibrin by thrombin.
(iv)Blood clotting involves cascading process involving a number of factors present always in the active form.

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  1. (i), (iii) and (iv)

  2. (ii) and (iv)

  3. (i)  and (iii)

  4. (iii) and (iv)

Show answer
Correct Option: C
Explanation:

Ca${+2}$ is necessary for blood coagulation -

1. Conversion of prothrombin to thrombin, in presence of prothrombin activator and Ca${+2)$
2. Conversion of fibrinogen monomers in to fibrin fibres  
III fibrinogen is thin soluable protein that is converted to insoluable protein fibres by thrombin
So, the correct answer is 'i and iii'

Identify $A,B$ and $C$ in the given blood clotting process.
Damage platelets release $A$;$A$ converts $D$ into $B$ in presence of Calcium ions. $B$ converts $C$ into Fibrin thread.

biology soldiers of defense blood clotting and healing of wounds coagulation of blood blood clotting

  1. A-Thromboplastin,B-Prothrombin,C-Fibrinogen

  2. A-Thrombin,B-Fibrinogen,C-Thrombo-kinase

  3. A-Thromboplastin,B-Thrombin,C-Fibrinogen

  4. A-Prothrombin,B-Thrombin,C-Fibrinogen

Show answer
Correct Option: A

Choose the correct answer from the four options given.
During blood coagulation, thromboplastin is released by?

biology soldiers of defense blood clotting and healing of wounds coagulation of blood blood clotting

  1. RBC

  2. Clumped platelets and damaged tissues

  3. Blood plasma

  4. Leucocyte

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Correct Option: A

The anticoagulant most commonly used to store blood in the blood banks is

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  1. Sodium nitrate

  2. Sodium fluoride

  3. EDTA

  4. Acid citrate dextrose

Show answer
Correct Option: D
Explanation:

Acid citrate dextrose solution (anticoagulant citrate dextrose solution) is a solution of citric acid, sodium citrate and dextrose in water. It is mainly used as an anticoagulant to preserve blood specimens required for tissue typing because it removes the calcium ion which plays an important role in blood clotting reaction.

Blood clot formed in vessels blocking the flow of the blood is called as the

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  1. Bolus

  2. Pus

  3. Ulcer

  4. Thrombus

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Correct Option: D
Explanation:
A thrombus is a blood clot that forms in a vessel and remains there. Clot leads to the coagulation of particles forming a thickened mass. It is traveled from the site of its production to another location in the body. It can block the flow of blood in that location depriving tissues of normal blood flow and oxygen. This can result in damage, destruction (infarction), or even death of the tissues (necrosis) in that area. 

Anticoagulant is 

biology soldiers of defense blood clotting and healing of wounds coagulation of blood blood clotting

  1. Citrate and oxalate

  2. Dicumarol

  3. Heparin

  4. All of the above

Show answer
Correct Option: D
Explanation:

All of them are anticoagulant. 'Citrate' is in liquid form and is used for coagulation tests, as well as in blood transfusion bags. It binds with the calcium ion, preventing the coagulation proteins from using them and thus prevent blood from clotting and this can be reversed with the addition of calcium. It can be in the form of sodium citrate or acid-citrate-dextrose.
'Oxalate' is an anticoagulant, which has a mechanism similar to that of citrate. It is used in fluoride oxalate tubes, used to determine glucose and lactate levels.
'Dicoumarol' is a naturally occurring anticoagulant that functions as a functional vitamin K depleter. It is also used in biochemical experiments as an inhibitor of reductases.
'Heparin' is widely used anticoagulant. It works by activating antithrombin III, which blocks thrombin from clotting blood. It can be used in vivo as an injectable anticoagulant. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines.

Thus, the correct answer is option D. 

You are required to draw blood from a patient and to keep it in a test tube for analysis of blood corpuscles and plasma. You are also produced with the following four types of test tubes. Which of them will you not use for the purpose?

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  1. Test tube containing calcium bicarbonate

  2. Chilled test tube

  3. Test tube containing heparin

  4. Test tube containing sodium oxalate

Show answer
Correct Option: A
Explanation:
  • Clotting of collected blood can be prevented by :
  • Coating test tubes with silicon (which produces non-wettable surface similar in its smoothness to the endothelial lining of blood vessels)
  • Adding chelating agents (includes trisodium citrate, sodium oxalate, and sodium EDTA) which remove calcium which is important for blood coagulation, and prevent blood clotting. Hence test tube containing calcium carbonate cannot be used.
  • Adding heparin, the most powerful anticoagulant which acts indirectly by activating plasma antithrombin III. 
  • Heparin is effective both in vivo and in vitro.
    Hence, the correct answer is A.

A drop of each of the following, is placed separately on four slides. Which one of them will not coagulate?

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  1. Blood serum

  2. Sample from thoracic duct of lymphatic system

  3. Whole blood from pulmonary vein

  4. Blood plasma

Show answer
Correct Option: A
Explanation:

Blood serum is the component of blood that has neither a blood cell nor a clotting factor. Serum includes all proteins not used in blood clotting (coagulation) and all the electrolytes, antibodies, antigens, hormones, and any exogenous substances (e.g., drugs and microorganisms). Hence, serum does not clot. Thus, the correct answer is option A.