Tag: immune system

Questions Related to immune system

GvHD occurs when 

  1. The host rejects the graft.

  2. The graft rejects the host.

  3. Host and graft reject each other.

  4. None of the above.


Correct Option: B

Which kind of graft is mostly preferred for burn patients?

  1. Isograft

  2. Autograft

  3. Allograft

  4. Xenograft


Correct Option: B
Explanation:

Autograft is a surgical transplantation of any tissue from one part of the body to another in the same individual. It is used in several kinds of plastic surgery, most commonly to replace skin lost in severe burns in which the open wound is usually covered with autograft.

So, the correct answer is option B.

Graft between individuals of different species is called 

  1. Xenograft

  2. Isograft

  3. Autograft

  4. Allograft


Correct Option: A
Explanation:
  • Grafting refers to a surgical procedure to move tissue from one site to another on the body, or from another creature, without bringing its own blood supply with it. Instead, a new blood supply grows in after it is placed.
  • There are 4 types of grafting techniques. They are Allograft, Autograft, Isograft and Xenograft.
  • Xenograft is the Grafting between two individuals of different species. Most commonly from animal to man such as pig heart valve used to replace human.
  • Hence Graft between individuals of different species is called  Xenograft.
  • So, the correct answer is 'Xenograft'.

Cyclosporin A is used for

  1. Dissolving blood clots

  2. Lowering cholesterol level

  3. Immunosuppression

  4. Enhancing tenderness of meat


Correct Option: C

After any graft/organ transplant, which medications does a patient have to take all his/her life

  1. Immuno modulators

  2. Immuno suppressants

  3. Immuno Competors

  4. Immuno stimulants


Correct Option: B
Explanation:
Immunosuppressants are drugs or medicines that lower the body's ability to reject a transplanted organ. Another term for these drugs is anti-rejection drugs. After an organ transplant, the patient needs to take immunosuppressant (anti-rejection) drugs. These drugs help prevent the immune system from attacking ("rejecting") the donor organ. Typically, they are taken for the lifetime of your transplanted organ. Other medications are taken to help the anti-rejection drugs do their job or control their side effects. Patients may also need to take medications for other health conditions.
So the correct option is 'immunosuppressants'.

Which of the following scientist got Nobel prize for research in organ transplantation and is also considered as the father of organ transplantation?

  1. Eduard Konrad Zirm

  2. Johns Hopkins

  3. Alexis Carrel

  4. Joseph Kelly


Correct Option: C
Explanation:

Alexis Carrel won noble prize for his research in organ transplantation in the year 1912. He's also considered as father of organ transplantation and vascular anastomosis.

So, the correct  option is 'Alexis Carrel'.

The first organ transplant in India was done at

  1. Adyar Cancer Institute, Chennai, Tamilnadu

  2. Christian Medical College, Vellore, Tamilnadu

  3. Deen Dayal Upadhyay Hospital, New Delhi

  4. King Edward Memorial Hospital, Mumbai, Maharashtra


Correct Option: D
Explanation:

The first organ transplant (kidney) performed in India was done at the King Edward Memorial Hospital at Bombay/Mumbai, Maharastra in May 1965.

So, the correct answer is option D.

Rejection of a transplant is an immune response of the type?

  1. B-lymphocyte mediated humoral response

  2. Helper T lymphocytes mediated humoral response

  3. Cell mediated involving cytotoxic T lymphocytes

  4. Cell mediated involving memory T lymphocytes


Correct Option: C
Explanation:

During transplantation of organs, rejection reactions may occur due to the activity of cytotoxic T lymphocytes in the recipient.

So, the correct option is 'Cell-mediated involving cytotoxic T lymphocytes'.

Major complication/s associated with prolonged glucocorticoidtherapy is/are

  1. Gastrointestinal ulcers

  2. Ostroporosis

  3. Increased secretion of HCI in stomach and pepsinogen

  4. All of these


Correct Option: D

Immunosuppressive drugs possess great risk of infection because

  1. These act against specific antigen

  2. These act against all the antigens

  3. These act on antigenic receptors

  4. None of the above


Correct Option: D
Explanation:

The immunosuppressive drugs are given to treat individuals with autoimmune disorders and to suppress immunity in order prevent host immune responses against antigens on the transplanted organ, thereby avoiding rejection. There are various kinds of immunosuppressive drugs; some drugs like Calcineurin inhibitors act on some of the immune cells which synthesize the receptors for antigen binding. None of the immunosuppressive drugs acts against antigens. However, use of the immunosuppressive drugs pose a risk of infection because they don't specifically inhibit certain cells that cause autoimmunity or transplant rejection, they inhibit the entire immune system making us vulnerable to infections. Thus, the correct answer is option D.